VDR is a gene which codes for a vitamin D receptor protein. This protein regulates calcium absorption and bone growth. A variant of the gene known as the rs2228570 (FokI polymorphism) is associated with a decrease in bone mineral density in white prepubescent girls.

The hnRNP C1/C2 component of the nuclear vitamin D receptor complex interacts with promoter regions of genes that are responsive to 1,25-dihydroxyvitamin D3 and can induce their transcription. The interaction is controlled by the reciprocal pattern and temporal on-and-off occupancy of the VDRE between the two components. It is also modulated by chromosomal positioning and binding preferences for specific hormones. Microarray studies in human cells show that more than 100 genes contain a VDRE. The VDRE is occupied by transcription repressors in the absence of 1,25-dihydroxyvitamin D3. The 1,25-dihydroxyvitamin D3-VDR complex binds to these genes, resulting in the recruitment of hnRNP C1/C2 and other proteins that can compete with the repressors and initiate transcription.

A virtual dataroom (VDR) can serve as a repository of information and documents relevant to legal, business transactions, or procedures. Viewing, downloading or printing is restricted. It makes use of central servers and an extranet connection which is an Internet connection that has restricted access, to offer restricted access to log-in for specific intervals gescheftmarketing.de/2021/09/01/how-much-icloud-storage-do-you-really-need/ during which users can access the data and documents.

Companies and investment banks that are involved in mergers and acquisitions are the most common users of a VDR. They require a secure platform for sharing information with investors or potential buyers in a clear and transparent manner and due diligence may require large amounts of data. Life science companies also use VDRs for everything from clinical trials results to HIPAA compliance documentation.